With a distinct mechanism of action, CUBICIN® (daptomycin for injection) kills bacteria without cytoplasm penetration and lysis1-3


  • Irreversibly binds to the cytoplasmic cell membrane of Gram-positive bacteria1-3
    • Calcium-dependent insertion of molecule into membrane
    • Oligomerization to form a pore or ion channel
  • Rapidly depolarizes the cell membrane, resulting in cell death3
CUBICIN Mechanism of Action

Artist interpretation of CUBICIN mechanism of action.

Learn about the pharmacokinetics of CUBICIN® (daptomycin for injection). »