CUBICIN® (daptomycin for injection) Dosing

Adult patients

  • Administer to adult patients intravenously in 0.9% sodium chloride, either by injection over a 2-minute period or by infusion over a 30-minute period
  • Recommended dosage regimen for adult patients:
Creatinine Clearance (CrCL) Dosage Regimen
cSSSI
For 7 to 14 days
S. aureus Bacteremia
For 2 to 6 weeks
≥30 mL/min 4 mg/kg once every 24 hours 6 mg/kg once every 24 hours
<30 mL/min, including hemodialysis and CAPD 4 mg/kg once every 48 hoursa 6 mg/kg once every 48 hoursa
  1. Administered following hemodialysis on hemodialysis days.

Pediatric patients

  • Unlike in adults, do NOT administer by injection over a two (2) minute period to pediatric patients
  • Administer to pediatric patients intravenously in 0.9% sodium chloride, by infusion over a 30- or 60-minute period, based on age
  • Recommended dosage regimen for pediatric patients (1 to 17 years of age) with cSSSI, based on age:
Age Group Dosageb Duration of Therapy
12 to 17 years 5 mg/kg once every 24 hours infused over 30 minutes Up to 14 days
7 to 11 years 7 mg/kg once every 24 hours infused over 30 minutes
2 to 6 years 9 mg/kg once every 24 hours infused over 60 minutes
1 to less than 2 years 10 mg/kg once every 24 hours infused over 60 minutes
  1. Recommended dosage is for pediatric patients (1 to 17 years of age) with normal renal function. Dosage adjustment for pediatric patients with renal impairment has not been established.
  • Recommended dosage regimen for pediatric patients (1 to 17 years of age) with S. aureus bacteremia, based on age:
Age Group Dosageb Duration of Therapy
12 to 17 years 7 mg/kg once every 24 hours infused over 30 minutes Up to 42 days
7 to 11 years 9 mg/kg once every 24 hours infused over 30 minutes
1 to 6 years 12 mg/kg once every 24 hours infused over 60 minutes
  1. Recommended dosage is for pediatric patients (1 to 17 years of age) with normal renal function. Dosage adjustment for pediatric patients with renal impairment has not been established.
  • There are two formulations of daptomycin that have differences concerning storage and reconstitution. Carefully follow the reconstitution and storage procedures in labeling
  • Do not use in conjunction with ReadyMED® elastomeric infusion pumps in adult and pediatric patients