There are important differences between CUBICIN® (daptomycin for injection) and CUBICIN® RF (daptomycin for injection) concerning storage and reconstitution

Vial-Storage Prior to Reconstitution
CUBICIN CUBICIN RF
Store original packages at refrigerated temperaturesb; avoid excessive heat Store original packages at room temperaturea; excursions permitted to 15°C to 30°C (59°F to 86°F)

aRoom temperature=20°C-25°C (68°F-77°F).
bRefrigerated temperatures=2°C-8°C (36°F-46°F).

Diluent for Vial Reconstitution
CUBICIN CUBICIN RF
0.9% sodium chloride Sterile water or bacteriostatic water.
Do NOT use saline based diluents for the reconstitution in the vial.
See section 2.8 of the Prescribing Information for incompatibilities

Preparation for Administration
CUBICIN CUBICIN RF
To minimize foaming, AVOID vigorous agitation or shaking of the vial during or after reconstitution...Ensure that all CUBICIN powder is wetted by gently rotating the vial. Allow the wetted product to stand undisturbed for 10 minutes. Gently rotate or swirl the vial contents for a few minutes, as needed, to obtain a completely reconstituted solution. Rotate or swirl the vial contents for a few minutes, as needed, to obtain a completely reconstituted solution.
See section 2.6 of the Prescribing Information for complete instructions on preparation

In-Use Shelf Life (once reconstituted)
Vial
  CUBICIN CUBICIN RF
In-Use Shelf Life (once reconstituted) Sodium chloride for injection Sterile water for injection Bacteriostatic water for injection
Room temperaturea: 12 hours 1 day 2 days
Refrigeratedb: 48 hours 3 days 3 days
Intravenous Bag
  CUBICIN CUBICIN RF
In-Use Shelf Life (once reconstituted) Reconstitution: 0.9% sodium chloride for injection for immediate dilution with 0.9% sodium chloride injection Reconstitution: Sterile water for injection for immediate dilution with 0.9% sodium chloride injection Reconstitution: Bacteriostatic water for injection for immediate dilution with 0.9% sodium chloride injection
Room temperaturea: 12 hours 19 hours 2 days
Refrigeratedb: 48 hours 3 days 5 days
Syringe*
  CUBICIN CUBICIN RF
In-Use Shelf Life (once reconstituted) No in-use shelf life specified in PI Sterile water for injection Bacteriostatic water for injection
Room temperaturea: 1 day 2 days
Refrigeratedb: 3 days 5 days

aRoom temperature=20°C-25°C (68°F-77°F).
bRefrigerated temperatures=2°C-8°C (36°F-46°F).
*Polypropylene syringe with elastomeric plunger stopper.